
最新最完整的蛋白質序列、模型、配體、及交互作用之資料庫與搜尋工具。代表產品:TIP, EVE, KKB。Eidogen的蛋白結構資訊整合(TIP: Target Informatics Platform)是世界上第一個整合蛋白結構和知識方法為主的系統。
Eidogen可以節省研究人員的實驗時間,例如給定系統蛋白序列或小分子去檢索,則可以馬上從全世界已發表的所蛋白結構中將相關的結構(包含小分子和蛋白之complex)找出來,並自動演算並疊合結構、小分子、和活性中心。有別於傳統的序列分析,提供研究人員以結構比較的概念來找出符合藥物結合的結構,或者是一系列的蛋白結構。
Eidogen的應用包括: ☆Target Prioritization Applications *Target Druggability Assessment ※Binding Site Property Analysis ※Binding Site Selectivity Analysis ※SNP structural mapping and analysis ※Drug Resistance Mutation Analysis ※Drug Target Clustering *Animal Model Suitability Analysis *Broad Spectrum Anti-Infective Target Analysis
☆Lead Discovery Applications *Novel Lead Fragment & Scaffold Discovery *Binding Site Property Analysis & HTS Library Selection *Structure-Based Library Design *VLS Binding Mode Analysis
☆Lead Optimization Applications *Structure-Based Ligand Affinity Optimization *Structure-Based Selectivity Optimization *Structure-Based Broad Spectrum Anti-Infective Optimization *Structure-Based Co-Inhibitor Affinity Optimization *"Off-Target" Discovery and Analysis *"Off-Target" Assay Panel Design
☆Opportunity Discovery *Novel Drug Rescue Opportunities ※Due to Drug-Induced Mutations ※Due to Poor Selectivity within a Family ※Due to "Off-Target" Interactions *Novel Drug Redesign Opportunities *Novel Drug Binding Site Opportunities *Novel Co-Inhibition Opportunities *Novel Anti-infective opportunities
|